Sulfamethoxazole and trimethoprim combination injection is used to treat infections including urinary tract infections and shigellosis. It is also used to treat Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP), a very serious kind of pneumonia. BACTRIMTM (trimethoprim and sulfamethoxazole) injection, a sterile solution for intravenous infusion only, is a combination of sulfamethoxazole, a sulfonamide antimicrobial, and trimethoprim, a. Bactrim and Bactrim DS contain a combination of two antibiotics, sulfamethoxazole and trimethoprim, that treat different types of infection caused by bacteria. Bactrim DS (double strength) tablets are twice as strong as Bactrim tablets. BACTRIM™ (trimethoprim and sulfamethoxazole) injection, a sterile solution for intravenous infusion only, is a combination of sulfamethoxazole, a sulfonamide antimicrobial, and trimethoprim, a dihydrofolate reductase inhibitor antibacterial. For IV trimethoprim-sulfamethoxazole, administer 8-12 mg/kg/day (based on the trimethoprim component) divided into either 4 doses IV or 2 doses for most bacterial infections, with infusion over 60-90 minutes. 1 Sulfamethoxazole and Trimethoprim Injection USP, a sterile solution for intravenous infusion only is a synthetic antibacterial combination product. Calculate trimethoprim-sulfamethoxazole dose for adults and children by weight and indication. Shows TMP and SMX components, formulation amounts for suspension, SS/DS tablets, and IV with dilution guidance. Trimethoprim-sulfamethoxazole (TMP-SMX), also known as co-trimoxazole, is a combination of two antimicrobial agents that act synergistically against a wide variety of bacteria. Although other combinations of sulfonamides are available with trimethoprim, TMP-SMX is by far the most widely used. Detailed Sulfamethoxazole / Trimethoprim dosage information for adults and children. Includes dosages for Urinary Tract Infection, Bronchitis, Cystitis and more; plus renal, liver and dialysis adjustments. In vitro serial dilution tests have shown that the spectrum of antibacterial activity of sulfamethoxazole and trimethoprim injection includes common bacterial pathogens with the exception of Pseudomonas aeruginosa.